Development and validation of stability indicating assay method of cetirizine hydrochloride by HPLC
نویسندگان
چکیده
منابع مشابه
Stability Indicating HPLC Method Development and Validation
High performance liquid chromatography (HPLC) is an integral analytical tool in assessing drug product stability. HPLC methods should be able to separate, detect, and quantify the various drug-related degradants that can form on storage or manufacturing, plus detect and quantify any drug-related impurities that may be introduced during synthesis. Forced degradation studies of new chemical entit...
متن کاملStability Indicating Assay Method Development and Validation to Simultaneously Estimate Metformin Hydrochloride and Canagliflozin by RP-HPLC
The focus of this study is to develop and validate a HPLC method to simultaneously estimatemetformin hydrochloride and canagliflozin in bulk using GraceSmart RP-18 column (250× 4.6mm, 5μ)at 30°C.Combination of acetonitrile(ACN) and ammonium acetate bufferin the ratio of 45:55v/v with pH 4.5 was used as mobile phase with 1ml/min flow rate. It was detected by photo diode array detector at 252 nm....
متن کاملDevelopment and Validation of a Stability indicating HPLC Assay Method for determination of Ticlopidine Hydrochloride in Tablet Formulation
The objective of the current study was to developed simple, precise and accurate isocratic reversedphase stability indicating HPLC assay method and validated for determination of ticlopidine hydrochloride in solid pharmaceutical dosage forms. Isocratic RP-HPLC separation was achieved on a Phenomenex Luna C8 (2) column (250 mm ́ 4.6 mm i.d., 5 μm particle size) using mobile phase of methanolammon...
متن کاملDevelopment and Validation of Stability Indicating HPLC Assay Method for Determination of Tapentadol in Tablet Formulation
The purpose of the research described herein was to develop simple, precise and accurate isocratic stability indicating reversed phase HPLC assay method for determination of Tapentadol solid dosage forms. Isocratic RP-HPLC method was developed on Phenomenex Luna C8 150 4.6mm, 5μm column using mobile phase as methanol – 0.002 M potassium dihydrogen phosphate buffer pH 3.0 (60: 40 v/v) at a flow...
متن کاملStability-Indicating HPLC Method for Determination of Nalbuphine Hydrochloride
A simple, sensitive, stability-indicating HPLC method was developed and validated for the quantitative determination of nalbuphine hydrochloride in presence of its degradation product.The analysis was carried out on a BDS Hypersil C18 ( 250 X 4.6 X 5μm particle size) using a mobile phase consisting of 5 mM sodium acetate buffer; pH 5.5: acetonitrile (40:60, v/v). The analysis was performed at a...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: African Journal of Pharmacy and Pharmacology
سال: 2011
ISSN: 1996-0816
DOI: 10.5897/ajpp10.283